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There was no beneficial effect of tocopherol or any interaction between tocopherol and deprenyl.The beneficial effects of deprenyl,which occurred largely during the first 12 months of treatment,remained strong and significantly delayed the onset of disability requiring levodopa therapy (hazard ratio,0.50;95 percent confidence interval,0.41 to 0.62;P<0.001). The difference in the estimated median time to the end point was about nine months.The ratings for Parkinson's disease improved during the first three months of deprenyl treatment;the motor performance of deprenyl- treated patients worsened after the treatments were withdrawn. |
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